BioIngine : Ingine Inc's Healthcare Data Science Venture
INGINE INC
The BioIngine.com
High Performance Medical Computational Thinking Learning and Reasoning System
Ingine - Partnership - BioEnterprise
Together Solve Medical Computational Thinking, Learning and Reasoning
The BioIngine.com
The BioIngine.com™, a medical computational thinking, learning and reasoning platform for the Healthcare market. The BioIngine delivers Medical Automated Reasoning Programming Language Environment (MARPLE) capability based on the mathematics borrowed from several disciplines and notably from late Prof Paul A M Dirac's Quantum Mechanics (QM). Particularly the mathematical technique derived from QM and based on Dirac Notation for knowledge inference is called Hyperbolic Dirac Net (HDN).
Research and Innovation
The BioIngine.com™ is a result of several years of efforts with Dr. Barry Robson; former Chief Scientific Officer, IBM Global Healthcare, Pharmaceutical and Life Sciences. His research has been in developing quantum math driven exchange and inference language achieving medical semantic interoperability, while also enabling Clinical Decision Support System based on the principles of Evidence Based Medicine (EBM) and its PICO (patient/problem/population-intervention-comparison-outcome) method.
BioEnterprise
BioEnterprise formed in 2002. Partner with people who have a passion for improving health and wellbeing. They are scientists, entrepreneurs, company founders with creativity and drive woven into their very DNA. Help them nurture innovative ideas and technologies from the embryonic stage, connecting them with critical resources and relationships, guiding them as they build their businesses, sell their products and services. We are experienced entrepreneurs and experts in rs grow their companies in Cleveland – The Medical Capital.
Healthcare Analytics and Medical Automated Reasoning
Quantum Mechanics Machinery for Big Data Driven Medicine
Hyperbolic Dirac Net
Bioingine.com employs algorithmic approach based on Hyperbolic Dirac Net that allows inference nets that are a general graph (GC), including cyclic paths, thus surpassing the limitation in the Bayes Net that is traditionally a Directed Acyclic Graph (DAG) by definition.
Probabilistic Knowledge
The Bioingine.com approach thus more fundamentally reflects the nature of probabilistic knowledge in the real world, which has the potential for taking account of the interaction between all things without limitation, and ironically this more explicitly makes use of Bayes rule far more than does a Bayes Net.
Deep Learning
It also allows more elaborate relationships than mere conditional dependencies, as a probabilistic semantics analogous to natural human language but with a more detailed sense of probability. To identify the things and their relationships that are important and provide the required probabilities, the Bioingine.com scouts the large complex data of both structured and also information of unstructured textual character.
Priori and Posterior Knowledge
It treats initial raw extracted knowledge rather in the manner of potentially erroneous or ambiguous prior knowledge, and validated and curated knowledge as posterior knowledge, and enables the refinement of knowledge extracted from authoritative scientific texts into an intuitive canonical “deep structure” mental-algebraic form that the Bioingine.com can more readily manipulate.
The BioIngine.com
MARPLE
The Medical Automated Reasoning Programming Language Environment
Dirac-Ingine :- Non Predicated Machine Learning
Is a data science approach that embraces Dirac Notation, employing Quantum-Universal Exchange Language (Q-UEL) and leading into Hyperbolic Dirac Nets (HDN - General Graphs) which include Bayes Nets (Directed Acyclic Graphs) option as subset.
Dirac-Miner :- Unsupervised Structured Data Mining
Is a machine learning (supervised and unsupervised) tool that employs Dirac Notation to extract knowledge (semantic triple store) from large data sets riddled with uncertainty. The extracted medical knowledge in terms of semantic triples or multiples), represented as Hyperbolic Dirac Net (HDN) Graphs, are placed in a Knowledge Representation Store (KRS).
Dirac-Inference : - HDN based Inference Mechanism from KRS
Is an inference tool, that based on a complex query, which is an ensemble of variables and measurements, scans the HDN based semantic triple store - Knowledge Representation Store (KRS), and finds the missing statements or paths that connect them so that overall, questions, statements between, and each answer in turn represents an HDN.
Dirac-Xtractor :- Unsupervised Unstructured Data Mining
Is a unsupervised unstructured web searching tool that employs Dirac Notation having strong relationship with the Semantic Structure used in the Semantic Web. The tool can quickly generate many millions of statements of knowledge. The extracted knowledge as semantic triples and semantic multiples are placed in the Knowledge Representation store.
Health Ecosystem Risk Stratification
Hyperbolic Dirac Net Inference (Probabilistic and Deterministic Reasoning)


Dirac-Ingine - Artificial Intelligence based Unsupervised Clinical Knowledge Inference From Large Data Sets
Hyperbolic Dirac Net - Machine Learning - Resolving Uncertainty
The Q-UEL Language
Q-UEL is an XML-like universal exchange language based on mutually consistent principles from physics, mathematics, artificial intelligence and semantics.
Dirac Notation
Based on the notation and associated algebra developed by Professor Paul A M Dirac, called the Dirac notation, bracket notation, or braket notation.
Quantum Algebra
It was first developed to handle uncertain observations and probabilistic inference in quantum mechanics.
Web Semantics
Integrates with web as an intelligent thinking entity, capable of reasoning to help humans make decisions.
Healthcare Performance based Outcomes
Driven by Clinical Efficacy
Efficacy of an Evidence-based Clinical Decision Support in Primary Care Practices http://www.ncbi.nlm.nih.gov/pubmed/23896675
The inherent uncertainty of medical knowledge renders it important to associate its representation with some kind of measure of probability, or degree of certainty, confidence, or scope. The modern approaches to medicine such as Evidence Based Medicine, Comparative Effectiveness Research and outcomes analysis are based on ideas of risk management and medical metrics that involve fundamentally probabilistic measures.
Patient Health
Public Health
Cardiovascular Disease Risk Factors
Cardiovascular Risk Calculator For Primary Prevention Using Framingham Risk Equation
Age
30%
Sex
40%
Body Mass Index
50%
Systolic BP
55%
Diastolic BP
45%
Total Cholesterol
60%
HDL Cholesterol
55%
Total /HDL Ratio
35%
Smoking Status
45%
Glucose
40%
Accountable Care Organization Quality Measures
Clinical Decision Support System Achieving Strategic Qualitative Outcomes
Patient/Caregiver Experience (7 Measures)
67%
Care Coordination/ Patient Safety (6 Measures)
43%
Preventive Health (8 Measures)
85%
At-Risk Population (12 Measures)
50%
20 %
Mortality Rate - - % of population dying of disease in a specified time during the epidemic
30 %
Fatality Rate - % of people with disease who die
40 %
Attack Rate - % of specified population acquiring disease in a specified time at the start of the epidemic
50 %
Incidence Rate - % of specified population acquiring disease in a specified time during the epidemic
Knowledge from Uncertainty by Probabilistic Inference
Evidence based Medicine - Clinical Decision Support System